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There are a number of Wordpress anti-spam plug-ins, the most recognizable one being Askimet. I've had several Wordpress blogs over the years and that one always did a good job of keeping spam away.
This article reviews several Wordpress spam plug-ins, but it makes an interesting point: Plug-ins eat up memory and slow down a blog, So the author recommends learning about built-in WordPress features that can help combat spam. One is the Default Article Settings, which allow you to eliminate pingback and trackback notifications -- and the plug-ins required to manage them.
Another helpful feature, under Other Comment Settings, requires the comment author to submit a name and email address.