IDG Answers is a community of experts who are passionate about technology. Ask a question or answer one below.
The answer, according to a couple of folks on this Apple support thread, is no:
"No. Providing no damage is caused during the installation."
"No. In fact your computer contains instructions on how to do so: >About this Mac>More Info>Memory."
But, again, you can't botch the job or all bets are off.