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I used to use Firefox exclusively, but I've switched to Chrome. As much as I hate to take off my little tinfoil hat and give one company my email, VoIP, documents, photographs and web browsing history, I find myself doing it more and more with Google. The main reason that I left Firefox for Chrome was speed. Secondarily, the amount of memory leaks with Firefox seemed to be getting worse and worse, especially with many of the extensions/applications. I haven't had many problems with Chrome since I started using it either, so it accomplished the browser trifecta for me: speed, less memory leakage and stability.
You might want to check out the "Web Browser Grand Prix" on tom's hardware for hard data on Opera, Chrome, Firefox, Safari, and IE. http://www.tomshardware.com/reviews/firefox-7-web-browser,3037.html It is an interesting article that benchmarks the top 5 web browsers flash performance, HTML5 performance, page load times and so on.