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I think a lot of the concern is driven by the press at the moment. We installed the hotfix that Microsoft released last week. Other than that, we have just followed our standard security practices. All of our updates are current, but that is SOP. Hopefully, this will be sufficient for the moment, but I am aware that there are a few duqu specific steps we could also take. It seems that duqu has had quite specific targets, and since we aren't in the nuclear power business or industrial control manufacturers, I think we are ok. Also, from what I understand, Duqu has essentially ran its course, and was only active for a set period last August. I realize that there may be subsequent variables, but the alarm has been sounded and the weaknesses exploited by Duqu identified.
If you are really worried about it, I saw that there is a free Duqu detector available.