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I experienced a TDSS infection a few months ago, despite the fact that my anti-virus software was up and current. It essentially made my laptop essentially unusable, and slowed browsing down so much it was like suddenly having an old 14.4 dial-up connection (remember those?). Even when I wasn't doing anything, I would get messages constantly that my computer was under attack and the anti-virus software was blocking it. When I could finally go to a new webpage, my anti-virus software would pop up warnings with each page. I was also getting redirected from the links that I tried to click on to completely unrelated sites. It was a headache.
In the end, the way I dealt with it was Kasperky's TDSS killer, which you can find at: