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Personally, I think registry cleaners are generally snake oil, and as you point out, they are often more likely to cause problems than resolve problems. That is not to say that there aren’t some legitimate needs for making changes to the registry. I had a laptop with a rootkit on it that caused registry problems, so that would be one example where it was helpful. Also, a lot of cleaners show tons and tons of “registry errors” that really aren’t errors, they are just registry keys that point to files that aren’t there any more. This is not a big deal. One of the things many people expect from registry cleaners is a faster PC after they use it. In my experience, they are going to be disappointed, because I have never seen that result.