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The top three things I would do would be:
1. Make sure that you have installed all of the updates/patches that Microsoft has released before May 13.
2. Remove any unused software and make sure to update anything that is left. Leave your antivirus software in place and make sure that it is updated.
3. Isolate the XP machines as much as possible. Remove them from your network if you can, increase restrictions as much as possible if you can’t.