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I think it’s easy for people to forget how complex computers really are, and how many processes are going on at any given moment. To keep everything in RAM precisely the way it ideally should be is nearly impossible, and when a computer is left running for days it becomes even harder. By restarting, the user clears the RAM and starts with a fresh page that is cleared of whatever caused the problem and everything is ok again. Of course, should the problem (whatever it might be) occur again it indicates that it is more of a problem that something just getting “messed up” in memory, and the issue is going to need to be identified and rectified.